Effects of Divorce on Children's Social Skills 1.
Now a team of researchers has completed the first study of the drug in adolescents, revealing strong remission rates for those young subjects with treatment-resistant depression. A huge amount of research is currently underway investigating the compelling, and novel, effects of ketamine on depression.
The entirely unique way the drug interacts with the brain is revealing new and exciting pathways for neuroscientists investigating everything from fatigue to suicidal thoughts. However, very little study has been undertaken into the effects of the drug on adolescents.
The impetus behind the research came from the hypothesis that the enhanced neuroplasticity of adolescent brains could help extend the duration of efficacy in ketamine treatments for depression, and potentially result in long-term benefits.
The researchers write in the study that, "adolescence is a key time period for emergence of depression and represents an opportune and critical developmental window for intervention to prevent negative outcomes.
All subjects were clinically diagnosed with treatment-resistant depression, meaning they had failed to respond to at least two prior antidepressant trials. The treatment involved six ketamine infusions over the course of two weeks, with doses based on body weight.
One week after the treatment, five of the 13 subjects displayed decreases in their symptoms to a level that could be clinically considered as remission. At the six week point following the treatment three subjects still displayed continued remission.
These results are slightly lower than what has been reported in adult studies, and the researchers hypothesize that dose could be a major factor in improving adolescent responses.
This means these subjects, four of which were overweight, received smaller doses than if it were actually calculated on real body weight. All five of these initial subjects displayed non-responsive results. The remaining eight subjects in the study were then dosed at a rate relative to their actual body weight.
Five of those eight subjects displayed successful remission responses. This suggests that dosing based on ideal body weight, which is known to be effective in adult subjects, may not be appropriate for adolescent subjects. While these results certainly confirm ketamine as offering significant benefits in treating major depression, there still is much work to be done to better understand the optimal dose and schedule for administering the drug, especially in younger patients.
Larger, and more long-term adolescent studies need to be completed to reveal how this drug interacts with growing, younger brains.Estimates from a study published in American Family Physician state that up to 15 percent of children and adolescents have some symptoms of depression..
The symptoms of depression can often be. Children in homes where one parent is abused may feel fearful and anxious. They may always be on guard, wondering when the next violent event will happen.
3 This can cause them to react in different ways, depending on their age: What are the long-term effects of domestic violence or abuse on. Major depression affects 3 to 5 percent of children and adolescents. Depression negatively impacts growth and development, school performance, and peer or family relationships and may lead to.
While plenty of studies have been conducted on using ketamine to treat depression in adults, there is a lack of research into how this drug . March Eligible Population Key Components Age-specific general recommendations Non-pharmacological treatment and education Pharmacotherapy leslutinsduphoenix.com The Children’s Depression Inventory (CDI and CDI2) is a psychological assessment that rates the severity of symptoms related to depression or dysthymic disorder in children and adolescents.
The CDI is a item scale that is self-rated and symptom-oriented. The assessment is now in its second edition. The 27 items on the assessment are grouped into five major factor areas.